InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFI6

Summary

InnateDB Protein

IDBP-94981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFI6

Protein Name

interferon, alpha-inducible protein 6

Synonyms

6-16; FAM14C; G1P3; IFI-6-16; IFI616;

Species

Homo sapiens

Ensembl Protein

ENSP00000342513

InnateDB Gene

IDBG-94975 (IFI6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	1 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051902	negative regulation of mitochondrial depolarization
GO:0060337	type I interferon signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR009311 Interferon alpha-inducible protein 6/27

PFAM

PF06140

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AK314488 AL445490 BC011601 BC015603 BN000257 BT006850 CH471059 U22970 X02492

GenPept

AAC50159 AAC50160 AAC50161 AAH11601 AAH15603 AAP35496 BAG37089 CAA26322 CAE12275 CAH72020 CAH72021 CAH72022 EAX07744 EAX07745 EAX07746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca