InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFI6

Summary

InnateDB Gene

IDBG-94975.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFI6

Gene Name

interferon, alpha-inducible protein 6

Synonyms

6-16; FAM14C; G1P3; IFI-6-16; IFI616

Species

Homo sapiens

Ensembl Gene

ENSG00000126709

Encoded Proteins

IDBP-94977

interferon, alpha-inducible protein 6

IDBP-94979

interferon, alpha-inducible protein 6

IDBP-94981

interferon, alpha-inducible protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15685448

IFI6 has a function as a cell survival protein by inhibiting mitochondrial-mediated apoptosis.

PMID 20939681

IFI6 (G1P3) gene encodes a low molecular weight mitochondrial protein that stabilizes mitochondrial function and opposes apoptosis.

Entrez Gene

Summary

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27666061-27672218

Strand

Reverse strand

Band

p35.3

Transcripts

ENST00000361157	ENSP00000354736
ENST00000362020	ENSP00000355152
ENST00000339145	ENSP00000342513

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	1 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051902	negative regulation of mitochondrial depolarization
GO:0060337	type I interferon signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P09912

TrEMBL

UniProt Splice Variant

Entrez Gene

2537

UniGene

RefSeq

NM_002038 NM_022872 NM_022873

HUGO

HGNC:4054

OMIM

147572

CCDS

CCDS306 CCDS307 CCDS308

HPRD

00959

IMGT

EMBL

AK314488 AL445490 BC011601 BC015603 BN000257 BT006850 CH471059 U22970 X02492

GenPept

AAC50159 AAC50160 AAC50161 AAH11601 AAH15603 AAP35496 BAG37089 CAA26322 CAE12275 CAH72020 CAH72021 CAH72022 EAX07744 EAX07745 EAX07746

RNA Seq Atlas

2537