InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR2E1

Summary

InnateDB Protein

IDBP-94995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR2E1

Protein Name

nuclear receptor subfamily 2, group E, member 1

Synonyms

TLL; TLX; XTLL;

Species

Homo sapiens

Ensembl Protein

ENSP00000357979

InnateDB Gene

IDBG-94991 (NR2E1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001662	behavioral fear response
GO:0002118	aggressive behavior
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007420	brain development
GO:0007601	visual perception
GO:0008284	positive regulation of cell proliferation
GO:0008347	glial cell migration
GO:0010467	gene expression
GO:0021542	dentate gyrus development
GO:0021764	amygdala development
GO:0021772	olfactory bulb development
GO:0021819	layer formation in cerebral cortex
GO:0021872	forebrain generation of neurons
GO:0021895	cerebral cortex neuron differentiation
GO:0021960	anterior commissure morphogenesis
GO:0021987	cerebral cortex development
GO:0030198	extracellular matrix organization
GO:0035019	somatic stem cell maintenance
GO:0035176	social behavior
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0045165	cell fate commitment
GO:0045665	negative regulation of neuron differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0048814	regulation of dendrite morphogenesis
GO:0051128	regulation of cellular component organization
GO:0060041	retina development in camera-type eye
GO:0060164	regulation of timing of neuron differentiation
GO:0060291	long-term synaptic potentiation
GO:0090049	regulation of cell migration involved in sprouting angiogenesis
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000179	positive regulation of neural precursor cell proliferation
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt