Version 5.4
Homo sapiens Gene: NR2E1
Summary
InnateDB Gene IDBG-94991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR2E1
Gene Name nuclear receptor subfamily 2, group E, member 1
Synonyms TLL; TLX; XTLL
Species Homo sapiens
Ensembl Gene ENSG00000112333
Encoded Proteins
IDBP-94993
nuclear receptor subfamily 2, group E, member 1
IDBP-94995
nuclear receptor subfamily 2, group E, member 1
IDBP-385802
nuclear receptor subfamily 2, group E, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:108166058-108188809
Strand Forward strand
Band q21
Transcripts
ENST00000368986 ENSP00000357982
ENST00000368983 ENSP00000357979
ENST00000426403 ENSP00000416908
ENST00000484978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001662 behavioral fear response
GO:0002118 aggressive behavior
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007420 brain development
GO:0007601 visual perception
GO:0008284 positive regulation of cell proliferation
GO:0008347 glial cell migration
GO:0010467 gene expression
GO:0021542 dentate gyrus development
GO:0021764 amygdala development
GO:0021772 olfactory bulb development
GO:0021819 layer formation in cerebral cortex
GO:0021872 forebrain generation of neurons
GO:0021895 cerebral cortex neuron differentiation
GO:0021960 anterior commissure morphogenesis
GO:0021987 cerebral cortex development
GO:0030198 extracellular matrix organization
GO:0035019 somatic stem cell maintenance
GO:0035176 social behavior
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0045165 cell fate commitment
GO:0045665 negative regulation of neuron differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045787 positive regulation of cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048712 negative regulation of astrocyte differentiation
GO:0048814 regulation of dendrite morphogenesis
GO:0051128 regulation of cellular component organization
GO:0060041 retina development in camera-type eye
GO:0060164 regulation of timing of neuron differentiation
GO:0060291 long-term synaptic potentiation
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000648 positive regulation of stem cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019803
View Gene Order
ENSBTAG00000013991
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y466
TrEMBL A6PVF6 B6ZGT9
UniProt Splice Variant
Entrez Gene 7101
UniGene Hs.157688
RefSeq NM_003269 NM_001286102
HUGO HGNC:7973
OMIM 603849
CCDS CCDS5063 CCDS69165
HPRD 07230
IMGT
EMBL AB307709 AF220532 AF411525 AK131541 AL078596 BC028031 CH471051 HQ692846 Y13276
GenPept AAG31945 AAH28031 AAL05871 ADZ17357 BAD18677 BAH02300 CAA73725 CAB75626 EAW48385 EAW48386
RNA Seq Atlas 7101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca