InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXO3

Summary

InnateDB Protein

IDBP-95026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXO3

Protein Name

forkhead box O3

Synonyms

AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000339527

InnateDB Gene

IDBG-95024 (FOXO3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269PubMed:10102273, ECO:0000269PubMed:16751106, ECO:0000269PubMed:21329882}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Disease Associations

Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with KMT2A/MLL1.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9479491}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	75 [view]
Protein-DNA	11 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006417	regulation of translation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034599	cellular response to oxidative stress
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling