Version 5.4
Homo sapiens Protein: SMPDL3B
Summary
InnateDB Protein IDBP-95114.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPDL3B
Protein Name sphingomyelin phosphodiesterase, acid-like 3B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362995
InnateDB Gene IDBG-95108 (SMPDL3B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006685 sphingomyelin catabolic process
GO:0008150 biological_process
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92485
PhosphoSite PhosphoSite-Q92485
TrEMBL
UniProt Splice Variant
Entrez Gene 27293
UniGene Hs.123659
RefSeq NP_001009568
HUGO HGNC:21416
OMIM
CCDS CCDS30656
HPRD 15405
IMGT
EMBL AK316500 AL512288 BC014444 CH471059 Y08134
GenPept AAH14444 BAH14871 CAA69328 CAI14293 CAI14294 EAX07721

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca