InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMPD2

Summary

InnateDB Protein

IDBP-95122.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMPD2

Protein Name

sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

Synonyms

ISC1; NSMASE; NSMASE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000258052

InnateDB Gene

IDBG-95120 (SMPD2)

Protein Structure

UniProt Annotation

Function

Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006684	sphingomyelin metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0009612	response to mechanical stimulus
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0046513	ceramide biosynthetic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097190	apoptotic signaling pathway