InnateDB Protein
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IDBP-95192.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATPIF1
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Protein Name
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ATPase inhibitory factor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000335203
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InnateDB Gene
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IDBG-95188 (ATPIF1)
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Protein Structure
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Function |
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. {ECO:0000269PubMed:12110673, ECO:0000269PubMed:15528193, ECO:0000269PubMed:19559621, ECO:0000269PubMed:23135403}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:12110673}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001525
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angiogenesis
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GO:0001937
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negative regulation of endothelial cell proliferation
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GO:0006091
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generation of precursor metabolites and energy
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GO:0006783
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heme biosynthetic process
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GO:0030218
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erythrocyte differentiation
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GO:0045980
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negative regulation of nucleotide metabolic process
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GO:0051260
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protein homooligomerization
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GO:0051289
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protein homotetramerization
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GO:0051346
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negative regulation of hydrolase activity
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GO:0072593
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reactive oxygen species metabolic process
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GO:1901030
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positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR007648
ATPase inhibitor, IATP, mitochondria
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PFAM |
PF04568
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UII2
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PhosphoSite |
PhosphoSite-Q9UII2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
93974
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UniGene |
Hs.743301
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RefSeq |
NP_057395
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HUGO |
HGNC:871
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OMIM |
614981
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CCDS |
CCDS319
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HPRD |
16529
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IMGT |
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EMBL |
AB029042
AF114836
AK316600
AL050386
AL353622
AL583540
AY005470
BC004955
BC009677
BT009849
CH471059
CR457097
DB030607
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GenPept |
AAF97495
AAH04955
AAH09677
AAP88851
AAP97235
BAA88422
BAG38187
CAG33378
CAI19134
CAI46227
EAX07704
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