InnateDB Protein
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IDBP-95213.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHACTR4
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Protein Name
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phosphatase and actin regulator 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362945
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InnateDB Gene
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IDBG-95211 (PHACTR4)
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Protein Structure
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Function |
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004018
RPEL repeat
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PFAM |
PF02755
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PRINTS |
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PIRSF |
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SMART |
SM00707
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IZ21
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PhosphoSite |
PhosphoSite-Q8IZ21
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
65979
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UniGene |
Hs.225641
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RefSeq |
NP_001041648
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HUGO |
HGNC:25793
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OMIM |
608726
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CCDS |
CCDS41293
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HPRD |
07816
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IMGT |
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EMBL |
AF130081
AK023233
AK025436
AL360012
AL670471
BC021247
BC029266
BC068508
CH471059
CR391992
CR589951
CR749449
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GenPept |
AAG35507
AAH21247
AAH29266
AAH68508
BAB14483
BAB15130
CAH18286
CAM12870
CAM12871
EAX07696
EAX07698
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