Version 5.4
Homo sapiens Gene: PHACTR4
Summary
InnateDB Gene IDBG-95211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHACTR4
Gene Name phosphatase and actin regulator 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204138
Encoded Proteins
IDBP-95213
phosphatase and actin regulator 4
IDBP-95219
phosphatase and actin regulator 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:28369603-28500369
Strand Forward strand
Band p35.3
Transcripts
ENST00000373839 ENSP00000362945
ENST00000373836 ENSP00000362942
ENST00000463428
ENST00000493669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008157 protein phosphatase 1 binding
GO:0071862 protein phosphatase type 1 activator activity
Biological Process
GO:0001755 neural crest cell migration
GO:0001843 neural tube closure
GO:0007266 Rho protein signal transduction
GO:0030036 actin cytoskeleton organization
GO:0043085 positive regulation of catalytic activity
GO:0048484 enteric nervous system development
GO:0051726 regulation of cell cycle
GO:0061386 closure of optic fissure
GO:2001045 negative regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066043
View Gene Order
ENSBTAG00000002727
Not yet available
Cross-References
SwissProt Q8IZ21
TrEMBL
UniProt Splice Variant
Entrez Gene 65979
UniGene Hs.225641
RefSeq NM_023923 XM_005245970 NM_001048183
HUGO HGNC:25793
OMIM 608726
CCDS CCDS41294 CCDS41293
HPRD 07816
IMGT
EMBL AF130081 AK023233 AK025436 AL360012 AL670471 BC021247 BC029266 BC068508 CH471059 CR391992 CR589951 CR749449
GenPept AAG35507 AAH21247 AAH29266 AAH68508 BAB14483 BAB15130 CAH18286 CAM12870 CAM12871 EAX07696 EAX07698
RNA Seq Atlas 65979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca