InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF12

Summary

InnateDB Protein

IDBP-95274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF12

Protein Name

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

Synonyms

TAF2J; TAFII20;

Species

Homo sapiens

Ensembl Protein

ENSP00000263974

InnateDB Gene

IDBG-95270 (TAF12)

Protein Structure

UniProt Annotation

Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11564863, ECO:0000269PubMed:9674425}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006352	DNA-templated transcription, initiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0043966	histone H3 acetylation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0000125	PCAF complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex

Protein Structure and Domains

PDB ID

InterPro

IPR003228 Transcription initiation factor TFIID
IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold

PFAM

PF03847
PF00808
PF00125

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16514

PhosphoSite