InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF12

Summary

InnateDB Gene

IDBG-95270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF12

Gene Name

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

Synonyms

TAF2J; TAFII20

Species

Homo sapiens

Ensembl Gene

ENSG00000120656

Encoded Proteins

IDBP-95272

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

IDBP-95274

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:28589323-28643085

Strand

Reverse strand

Band

p35.3

Transcripts

ENST00000373824	ENSP00000362930
ENST00000263974	ENSP00000263974
ENST00000471683
ENST00000495422

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006352	DNA-templated transcription, initiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0043966	histone H3 acetylation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0000125	PCAF complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex