Version 5.4
Homo sapiens Protein: YTHDF2
Summary
InnateDB Protein IDBP-95298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YTHDF2
Protein Name YTH domain family, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362918
InnateDB Gene IDBG-95296 (YTHDF2)
Protein Structure
UniProt Annotation
Function Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. {ECO:0000269PubMed:22575960, ECO:0000269PubMed:24284625}.
Subcellular Localization Cytoplasm, P-body {ECO:0000269PubMed:24284625}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:1990247 N6-methyladenosine-containing RNA binding
Biological Process
GO:0006959 humoral immune response
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
Protein Structure and Domains
PDB ID
InterPro IPR007275 YTH domain
PFAM PF04146
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5A9
PhosphoSite PhosphoSite-Q9Y5A9
TrEMBL S4R3J8
UniProt Splice Variant
Entrez Gene 51441
UniGene Hs.532286
RefSeq NP_057342
HUGO HGNC:31675
OMIM 610640
CCDS CCDS41296
HPRD 06587
IMGT
EMBL AF155095 AF192968 AF432214 AK292581 AK303833 AL356786 AL645729 BC002559 CH471059
GenPept AAD42861 AAF08813 AAH02559 AAL99921 BAF85270 BAG64779 CAH72429 CAI21658 EAX07673 EAX07674 EAX07675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca