Version 5.4
Homo sapiens Gene: YTHDF2
Summary
InnateDB Gene IDBG-95296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YTHDF2
Gene Name YTH domain family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198492
Encoded Proteins
IDBP-95298
YTH domain family, member 2
IDBP-813290
YTH domain family, member 2
IDBP-813293
YTH domain family, member 2
IDBP-590853
YTH domain family, member 2
IDBP-583365
YTH domain family, member 2
IDBP-813294
YTH domain family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:28736621-28769775
Strand Forward strand
Band p35.3
Transcripts
ENST00000373812 ENSP00000362918
ENST00000474884 ENSP00000474446
ENST00000478283
ENST00000496288 ENSP00000474784
ENST00000475796
ENST00000476976
ENST00000468863
ENST00000542507 ENSP00000444660
ENST00000541996 ENSP00000439394
ENST00000621244 ENSP00000481408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
GO:1990247 N6-methyladenosine-containing RNA binding
Biological Process
GO:0006959 humoral immune response
GO:0043488 regulation of mRNA stability
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040025
View Gene Order
ENSBTAG00000015771
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532286
RefSeq NM_001172828 NM_001173128 NM_016258
HUGO
OMIM
CCDS CCDS41296 CCDS53287
HPRD 06587
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca