InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REV3L

Summary

InnateDB Protein

IDBP-95370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REV3L

Protein Name

REV3-like, catalytic subunit of DNA polymerase zeta (yeast)

Synonyms

POLZ; REV3;

Species

Homo sapiens

Ensembl Protein

ENSP00000357795

InnateDB Gene

IDBG-95364 (REV3L)

Protein Structure

UniProt Annotation

Function

Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0019985	translesion synthesis

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0016035	zeta DNA polymerase complex

Protein Structure and Domains

PDB ID

InterPro

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain

PFAM

PF03104
PF00136

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt