InnateDB Protein
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IDBP-95394.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PUM1
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Protein Name
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pumilio homolog 1 (Drosophila)
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Synonyms
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HSPUM; PUMH; PUMH1; PUML1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000257075
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InnateDB Gene
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IDBG-95392 (PUM1)
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Protein Structure
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Function |
Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells. {ECO:0000269PubMed:21397187, ECO:0000269PubMed:22955276}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269PubMed:12459267}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001313
Pumilio RNA-binding repeat
IPR016024
Armadillo-type fold
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PFAM |
PF00806
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PRINTS |
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PIRSF |
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SMART |
SM00025
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TIGRFAMs |
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Modification |
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SwissProt |
Q14671
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PhosphoSite |
PhosphoSite-Q14671
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TrEMBL |
E9PL65
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UniProt Splice Variant |
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Entrez Gene |
9698
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UniGene |
Hs.641752
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RefSeq |
NP_055491
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HUGO |
HGNC:14957
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OMIM |
607204
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CCDS |
CCDS338
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HPRD |
06230
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IMGT |
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EMBL |
AF315592
AK222605
AK291779
AK294477
AL356320
AL445235
BC013398
CH471059
D43951
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GenPept |
AAG31807
AAH13398
BAA07895
BAD96325
BAF84468
BAG57703
CAH71203
CAI22246
EAX07633
EAX07634
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