Version 5.4
Homo sapiens Gene: PUM1
Summary
InnateDB Gene IDBG-95392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUM1
Gene Name pumilio homolog 1 (Drosophila)
Synonyms HSPUM; PUMH; PUMH1; PUML1
Species Homo sapiens
Ensembl Gene ENSG00000134644
Encoded Proteins
IDBP-95394
pumilio homolog 1 (Drosophila)
IDBP-95398
pumilio homolog 1 (Drosophila)
IDBP-95400
pumilio homolog 1 (Drosophila)
IDBP-95402
pumilio homolog 1 (Drosophila)
IDBP-378063
pumilio homolog 1 (Drosophila)
IDBP-378064
pumilio homolog 1 (Drosophila)
IDBP-378065
pumilio homolog 1 (Drosophila)
IDBP-586977
pumilio homolog 1 (Drosophila)
IDBP-590334
pumilio homolog 1 (Drosophila)
IDBP-587279
pumilio homolog 1 (Drosophila)
IDBP-602065
pumilio homolog 1 (Drosophila)
IDBP-600098
pumilio homolog 1 (Drosophila)
IDBP-593989
pumilio homolog 1 (Drosophila)
IDBP-585212
pumilio homolog 1 (Drosophila)
IDBP-599718
pumilio homolog 1 (Drosophila)
IDBP-589189
pumilio homolog 1 (Drosophila)
IDBP-590946
pumilio homolog 1 (Drosophila)
IDBP-591635
pumilio homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3\' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:30931506-31065991
Strand Reverse strand
Band p35.2
Transcripts
ENST00000257075 ENSP00000257075
ENST00000373747 ENSP00000362852
ENST00000373742 ENSP00000362847
ENST00000373741 ENSP00000362846
ENST00000424085 ENSP00000400141
ENST00000426105 ENSP00000391723
ENST00000440538 ENSP00000401777
ENST00000498419 ENSP00000433850
ENST00000498627
ENST00000471894
ENST00000490546
ENST00000480602 ENSP00000437269
ENST00000525843 ENSP00000435825
ENST00000530669 ENSP00000434096
ENST00000529846 ENSP00000431213
ENST00000525997 ENSP00000433373
ENST00000527498 ENSP00000431779
ENST00000532678 ENSP00000435589
ENST00000526128
ENST00000526215 ENSP00000436921
ENST00000525948 ENSP00000433099
ENST00000524516
ENST00000531867 ENSP00000431470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
GO:0006892 post-Golgi vesicle-mediated transport
GO:0061024 membrane organization
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028580
View Gene Order
ENSBTAG00000018979
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PL65
UniProt Splice Variant
Entrez Gene 9698
UniGene Hs.281707 Hs.641752
RefSeq NM_001020658 NM_014676
HUGO HGNC:14957
OMIM 607204
CCDS CCDS338 CCDS44099
HPRD 06230
IMGT
EMBL AL356320 AL445235
GenPept
RNA Seq Atlas 9698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca