InnateDB Protein
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IDBP-95429.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRAF3IP2
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Protein Name
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TRAF3 interacting protein 2
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Synonyms
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ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357750
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InnateDB Gene
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IDBG-95427 (TRAF3IP2)
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Protein Structure
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Function |
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
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Subcellular Localization |
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Disease Associations |
Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269PubMed:20953186, ECO:0000269PubMed:20953188}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:24120361}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013568
SEFIR
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PFAM |
PF08357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43734
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PhosphoSite |
PhosphoSite-O43734
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10758
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UniGene |
Hs.561514
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RefSeq |
NP_679211
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HUGO |
HGNC:1343
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OMIM |
607043
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CCDS |
CCDS5093
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HPRD |
06129
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IMGT |
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EMBL |
AF136405
AF136406
AF136407
AF272151
AF274303
AK025351
AK026602
AK314415
AL008730
AL050289
BC002823
BI856094
CH471051
Z97989
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GenPept |
AAF67445
AAF67446
AAF67447
AAG15367
AAG15407
AAH02823
BAB15117
BAB15507
BAG37036
CAA15506
CAA15507
CAB43390
CAD92596
CAD92597
CAI22297
CAI22298
EAW48285
EAW48287
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