Version 5.4
Homo sapiens Gene: TRAF3IP2
Summary
InnateDB Gene IDBG-95427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF3IP2
Gene Name TRAF3 interacting protein 2
Synonyms ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13
Species Homo sapiens
Ensembl Gene ENSG00000056972
Encoded Proteins
IDBP-95429
TRAF3 interacting protein 2
IDBP-95431
TRAF3 interacting protein 2
IDBP-95433
TRAF3 interacting protein 2
IDBP-95435
TRAF3 interacting protein 2
IDBP-245418
TRAF3 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:111556454-111606278
Strand Reverse strand
Band q21
Transcripts
ENST00000368761 ENSP00000357750
ENST00000359831 ENSP00000352889
ENST00000340026 ENSP00000345984
ENST00000368735 ENSP00000357724
ENST00000368734
ENST00000368731
ENST00000368730
ENST00000392556 ENSP00000376339
ENST00000492671
ENST00000464903
ENST00000532708
ENST00000528599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 39 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0048305 immunoglobulin secretion
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019842
View Gene Order
ENSBTAG00000008600
Not yet available
Cross-References
SwissProt O43734
TrEMBL
UniProt Splice Variant
Entrez Gene 10758
UniGene Hs.561514
RefSeq NM_001164281 NM_001164283 NM_147686 XM_006715319
HUGO HGNC:1343
OMIM 607043
CCDS CCDS5093 CCDS55049 CCDS55050
HPRD
IMGT
EMBL AF136405 AF136406 AF136407 AF272151 AF274303 AK025351 AK026602 AK314415 AL008730 AL050289 BC002823 BI856094 CH471051 Z97989
GenPept AAF67445 AAF67446 AAF67447 AAG15367 AAG15407 AAH02823 BAB15117 BAB15507 BAG37036 CAA15506 CAA15507 CAB43390 CAD92596 CAD92597 CAI22297 CAI22298 EAW48285 EAW48287
RNA Seq Atlas 10758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca