InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAF3IP2

Summary

InnateDB Protein

IDBP-95435.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF3IP2

Protein Name

TRAF3 interacting protein 2

Synonyms

ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; CIKS; PSORS13;

Species

Homo sapiens

Ensembl Protein

ENSP00000357724

InnateDB Gene

IDBG-95427 (TRAF3IP2)

Protein Structure

UniProt Annotation

Function

Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

Subcellular Localization

Disease Associations

Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269PubMed:20953186, ECO:0000269PubMed:20953188}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269PubMed:24120361}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.