InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TINAGL1

Summary

InnateDB Protein

IDBP-95457.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TINAGL1

Protein Name

tubulointerstitial nephritis antigen-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000271064

InnateDB Gene

IDBG-95453 (TINAGL1)

Protein Structure

UniProt Annotation

Function

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:10799322, ECO:0000269PubMed:11170462}.

Disease Associations

Tissue Specificity

Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney. {ECO:0000269PubMed:11170462}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005201	extracellular matrix structural constituent
GO:0008234	cysteine-type peptidase activity
GO:0030247	polysaccharide binding
GO:0043236	laminin binding