InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL16A1

Summary

InnateDB Protein

IDBP-95483.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL16A1

Protein Name

collagen, type XVI, alpha 1

Synonyms

447AA;

Species

Homo sapiens

Ensembl Protein

ENSP00000362776

InnateDB Gene

IDBG-95481 (COL16A1)

Protein Structure

UniProt Annotation

Function

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. {ECO:0000269PubMed:16754661}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:9022684}.

Disease Associations

Tissue Specificity

In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is found in the amnion, a membranous tissue lining the amniotic cavity. Within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers. Also located to a fibroblast layer beneath this dense layer. Exists in tissues in association with other types of collagen. {ECO:0000269PubMed:12782140}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007565	female pregnancy
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0071230	cellular response to amino acid stimulus