InnateDB Protein
|
IDBP-95542.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
KHDRBS1
|
Protein Name
|
KH domain containing, RNA binding, signal transduction associated 1
|
Synonyms
|
p62; p68; Sam68;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000313829
|
InnateDB Gene
|
IDBG-95540 (KHDRBS1)
|
Protein Structure
|
|
Function |
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). {ECO:0000269PubMed:22253824}.Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269PubMed:9013542}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:1374686}. Membrane {ECO:0000269PubMed:1374686}.
|
Disease Associations |
|
Tissue Specificity |
Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. {ECO:0000269PubMed:9013542}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 198 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
13 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR004087
K Homology domain
IPR004088
K Homology domain, type 1
|
PFAM |
PF00013
PF13014
|
PRINTS |
|
PIRSF |
|
SMART |
SM00322
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q07666
|
PhosphoSite |
PhosphoSite-Q07666
|
TrEMBL |
B4E043
|
UniProt Splice Variant |
|
Entrez Gene |
10657
|
UniGene |
Hs.732508
|
RefSeq |
NP_006550
|
HUGO |
HGNC:18116
|
OMIM |
602489
|
CCDS |
CCDS350
|
HPRD |
03926
|
IMGT |
|
EMBL |
AK091346
AK303218
AL139249
AL445248
BC000717
BC010132
BC019109
CH471059
M88108
U78971
|
GenPept |
AAA59990
AAB47504
AAH00717
AAH10132
AAH19109
BAC03643
BAG64305
CAH71944
CAH71945
CAI21971
CAI21972
EAX07575
EAX07576
EAX07577
|
|
|