Version 5.4
Homo sapiens Protein: RNF19B
Summary
InnateDB Protein IDBP-95847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF19B
Protein Name ring finger protein 19B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362555
InnateDB Gene IDBG-95845 (RNF19B)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. {ECO:0000269PubMed:10438909, ECO:0000269PubMed:16709802}.
Subcellular Localization Cytoplasmic granule membrane {ECO:0000269PubMed:10438909}; Multi-pass membrane protein {ECO:0000269PubMed:10438909}.
Disease Associations
Tissue Specificity Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level). {ECO:0000269PubMed:10438909, ECO:0000269PubMed:10912506}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0042267 natural killer cell mediated cytotoxicity
GO:0072643 interferon-gamma secretion
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0044194 cytolytic granule
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR002867 Zinc finger, C6HC-type
PFAM PF13639
PF14634
PF01485
PRINTS
PIRSF
SMART SM00184
SM00647
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMZ0
PhosphoSite PhosphoSite-Q6ZMZ0
TrEMBL
UniProt Splice Variant
Entrez Gene 127544
UniGene Hs.602585
RefSeq NP_699172
HUGO HGNC:26886
OMIM 610872
CCDS CCDS372
HPRD 13725
IMGT
EMBL AK074486 AK131439 AL031602 BC020595 BC062374 BC113560 BC143687 CH471059
GenPept AAH20595 AAH62374 AAI13561 AAI43688 BAC11017 BAD18585 EAX07490 EAX07491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca