InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLN

Summary

InnateDB Protein

IDBP-95887.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLN

Protein Name

phospholamban

Synonyms

CMD1P; CMH18; PLB;

Species

Homo sapiens

Ensembl Protein

ENSP00000350132

InnateDB Gene

IDBG-95885 (PLN)

Protein Structure

UniProt Annotation

Function

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. {ECO:0000269PubMed:22427649, ECO:0000269PubMed:22707725}.

Subcellular Localization

Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Cardiomyopathy, dilated 1P (CMD1P) [MIM:609909]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:12610310, ECO:0000269PubMed:16432188}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, familial hypertrophic 18 (CMH18) [MIM:613874]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:12705874}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Heart muscle (at protein level). {ECO:0000269PubMed:17241641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0042030	ATPase inhibitor activity
GO:0042802	identical protein binding
GO:0051117	ATPase binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0008015	blood circulation
GO:0008016	regulation of heart contraction
GO:0010043	response to zinc ion
GO:0010459	negative regulation of heart rate
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0032780	negative regulation of ATPase activity
GO:0032868	response to insulin
GO:0033574	response to testosterone
GO:0043086	negative regulation of catalytic activity
GO:0045822	negative regulation of heart contraction
GO:0048738	cardiac muscle tissue development
GO:0051260	protein homooligomerization
GO:0051480	cytosolic calcium ion homeostasis
GO:0051924	regulation of calcium ion transport
GO:0051926	negative regulation of calcium ion transport
GO:0055119	relaxation of cardiac muscle
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086023	adrenergic receptor signaling pathway involved in heart process
GO:0086036	regulation of cardiac muscle cell membrane potential
GO:0086092	regulation of the force of heart contraction by cardiac conduction
GO:0090279	regulation of calcium ion import
GO:0090281	negative regulation of calcium ion import
GO:1901020	negative regulation of calcium ion transmembrane transporter activity
GO:1901077	regulation of relaxation of muscle
GO:1901877	negative regulation of calcium ion binding
GO:1901894	regulation of calcium-transporting ATPase activity
GO:1901895	negative regulation of calcium-transporting ATPase activity
GO:1901897	regulation of relaxation of cardiac muscle
GO:1902081	negative regulation of calcium ion import into sarcoplasmic reticulum

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0031966	mitochondrial membrane
GO:0031982	vesicle
GO:0033017	sarcoplasmic reticulum membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0090534	calcium ion-transporting ATPase complex