Version 5.4
Homo sapiens Gene: PLN
Summary
InnateDB Gene IDBG-95885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLN
Gene Name phospholamban
Synonyms CMD1P; CMH18; PLB
Species Homo sapiens
Ensembl Gene ENSG00000198523
Encoded Proteins
IDBP-95887
phospholamban
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:118548298-118560730
Strand Forward strand
Band q22.31
Transcripts
ENST00000357525 ENSP00000350132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0042030 ATPase inhibitor activity
GO:0042802 identical protein binding
GO:0051117 ATPase binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0010043 response to zinc ion
GO:0010459 negative regulation of heart rate
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0032780 negative regulation of ATPase activity
GO:0032868 response to insulin
GO:0033574 response to testosterone
GO:0043086 negative regulation of catalytic activity
GO:0045822 negative regulation of heart contraction
GO:0048738 cardiac muscle tissue development
GO:0051260 protein homooligomerization
GO:0051480 cytosolic calcium ion homeostasis
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0055119 relaxation of cardiac muscle
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086023 adrenergic receptor signaling pathway involved in heart process
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0086092 regulation of the force of heart contraction by cardiac conduction
GO:0090279 regulation of calcium ion import
GO:0090281 negative regulation of calcium ion import
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:1901077 regulation of relaxation of muscle
GO:1901877 negative regulation of calcium ion binding
GO:1901894 regulation of calcium-transporting ATPase activity
GO:1901895 negative regulation of calcium-transporting ATPase activity
GO:1901897 regulation of relaxation of cardiac muscle
GO:1902081 negative regulation of calcium ion import into sarcoplasmic reticulum
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0031966 mitochondrial membrane
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0090534 calcium ion-transporting ATPase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038583
View Gene Order
ENSBTAG00000012931
Not yet available
Pathways
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt P26678
TrEMBL Q5R352
UniProt Splice Variant
Entrez Gene 5350
UniGene Hs.170839
RefSeq NM_002667
HUGO HGNC:9080
OMIM 172405
CCDS CCDS5120
HPRD
IMGT
EMBL AF177764 AK311799 BC005269 CH471051 M60411 M63603
GenPept AAA60083 AAA60109 AAD55950 AAH05269 BAG34742 EAW48198
RNA Seq Atlas 5350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca