Version 5.4
Homo sapiens Protein: MCM9
Summary
InnateDB Protein IDBP-95910.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM9
Protein Name minichromosome maintenance complex component 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312870
InnateDB Gene IDBG-95904 (MCM9)
Protein Structure
UniProt Annotation
Function Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. {ECO:0000269PubMed:22771115}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Localizes to nuclear foci and colocalizes with RAD51. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006974 cellular response to DNA damage stimulus
GO:0007292 female gamete generation
Cellular Component
GO:0005634 nucleus
GO:0097362 MCM8-MCM9 complex
Protein Structure and Domains
PDB ID
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00493
PRINTS PR01657
PIRSF
SMART SM00350
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXL9
PhosphoSite PhosphoSite-Q9NXL9
TrEMBL D6RHY8
UniProt Splice Variant
Entrez Gene 254394
UniGene Hs.736853
RefSeq NP_694987
HUGO HGNC:21484
OMIM 610098
CCDS CCDS5121
HPRD 17472
IMGT
EMBL ABBA01026024 AK000177 AK299076 AL132874 AL359634 BC031658 BN000882
GenPept AAH31658 BAA90991 BAG61142 CAJ70648 CAX30832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca