Version 5.4
Homo sapiens Protein: CLSPN
Summary
InnateDB Protein IDBP-96226.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLSPN
Protein Name claspin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000251195
InnateDB Gene IDBG-96222 (CLSPN)
Protein Structure
UniProt Annotation
Function Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. {ECO:0000269PubMed:12766152, ECO:0000269PubMed:15096610, ECO:0000269PubMed:15190204, ECO:0000269PubMed:15226314, ECO:0000269PubMed:15707391}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12766152}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0010997 anaphase-promoting complex binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0018105 peptidyl-serine phosphorylation
GO:0031572 G2 DNA damage checkpoint
GO:0032147 activation of protein kinase activity
GO:0033314 mitotic DNA replication checkpoint
Cellular Component
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HAW4
PhosphoSite PhosphoSite-Q9HAW4
TrEMBL
UniProt Splice Variant
Entrez Gene 63967
UniGene Hs.175613
RefSeq
HUGO HGNC:19715
OMIM 605434
CCDS
HPRD 09257
IMGT
EMBL AF297866 AL354864 BC038991 BC062215 BC113116 BC115025 BC137279 BC140789
GenPept AAG24515 AAH38991 AAH62215 AAI13117 AAI15026 AAI37280 AAI40790 CAH73807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca