Version 5.4
Homo sapiens Gene: CLSPN
Summary
InnateDB Gene IDBG-96222.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLSPN
Gene Name claspin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092853
Encoded Proteins
IDBP-96226
claspin
IDBP-96228
claspin
IDBP-96230
claspin
IDBP-477680
claspin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:35720218-35769967
Strand Reverse strand
Band p34.3
Transcripts
ENST00000251195 ENSP00000251195
ENST00000373220 ENSP00000362317
ENST00000318121 ENSP00000312995
ENST00000466308
ENST00000520551 ENSP00000428848
ENST00000517467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0010997 anaphase-promoting complex binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0018105 peptidyl-serine phosphorylation
GO:0031572 G2 DNA damage checkpoint
GO:0032147 activation of protein kinase activity
GO:0033314 mitotic DNA replication checkpoint
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042489
View Gene Order
ENSBTAG00000002826
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_578
Apoptosis pathway
REACT_115566
Cell Cycle pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
INOH
PID NCI
atr_pathway
ATR signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.175613
RefSeq NM_001190481 NM_022111
HUGO
OMIM
CCDS CCDS396 CCDS53297
HPRD 09257
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca