InnateDB Protein
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IDBP-96230.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLSPN
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Protein Name
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claspin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000312995
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InnateDB Gene
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IDBG-96222 (CLSPN)
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Protein Structure
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Function |
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. {ECO:0000269PubMed:12766152, ECO:0000269PubMed:15096610, ECO:0000269PubMed:15190204, ECO:0000269PubMed:15226314, ECO:0000269PubMed:15707391}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12766152}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HAW4
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PhosphoSite |
PhosphoSite-Q9HAW4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
63967
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UniGene |
Hs.175613
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RefSeq |
NP_071394
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HUGO |
HGNC:19715
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OMIM |
605434
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CCDS |
CCDS396
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HPRD |
09257
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IMGT |
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EMBL |
AF297866
AL354864
BC038991
BC062215
BC113116
BC115025
BC137279
BC140789
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GenPept |
AAG24515
AAH38991
AAH62215
AAI13117
AAI15026
AAI37280
AAI40790
CAH73807
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