InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2C3

Summary

InnateDB Protein

IDBP-96258.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2C3

Protein Name

eukaryotic translation initiation factor 2C, 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000246314

InnateDB Gene

IDBG-96250 (EIF2C3)

Protein Structure

UniProt Annotation

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. {ECO:0000255HAMAP- Rule:MF_03032, ECO:0000269PubMed:18771919, ECO:0000269PubMed:23064648}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03032, ECO:0000269PubMed:16081698}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.

Experimentally validated
Total	66 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0035198	miRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006402	mRNA catabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0072091	regulation of stem cell proliferation