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InnateDB Protein
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IDBP-96266.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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THEMIS
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Protein Name
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thymocyte selection associated
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357233
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InnateDB Gene
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IDBG-96262 (THEMIS)
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Protein Structure
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| Function |
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
3
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
4 [view]
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q8N1K5
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
387357
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| UniGene |
Hs.661756
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| RefSeq |
XP_006715539
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| HUGO |
HGNC:21569
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| OMIM |
613607
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| CCDS |
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| HPRD |
16662
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4