Version 5.4
Homo sapiens Protein: THEMIS
Summary
InnateDB Protein IDBP-96268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THEMIS
Protein Name thymocyte selection associated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357231
InnateDB Gene IDBG-96262 (THEMIS)
Protein Structure
UniProt Annotation
Function Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043368 positive T cell selection
GO:0043383 negative T cell selection
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N1K5
PhosphoSite PhosphoSite-Q8N1K5
TrEMBL
UniProt Splice Variant
Entrez Gene 387357
UniGene Hs.661756
RefSeq NP_001158157
HUGO HGNC:21569
OMIM 613607
CCDS CCDS34534
HPRD 16662
IMGT
EMBL AK094863 AK097903 AK124031 AK128377 AK292046 AL035470 AL356432 AL365224 BC130516 BX640890 CH471051
GenPept AAI30517 BAC05194 BAF84735 BAG52943 BAG53994 BAG54669 CAE45941 CAI13396 CAI13397 CAI17110 CAI17111 EAW48092

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca