InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRK

Summary

InnateDB Protein

IDBP-96278.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRK

Protein Name

protein tyrosine phosphatase, receptor type, K

Synonyms

R-PTP-kappa;

Species

Homo sapiens

Ensembl Protein

ENSP00000357209

InnateDB Gene

IDBG-96274 (PTPRK)

Protein Structure

UniProt Annotation

Function

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269PubMed:19836242}.

Subcellular Localization

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0030336	negative regulation of cell migration
GO:0034394	protein localization to cell surface
GO:0034614	cellular response to reactive oxygen species
GO:0034644	cellular response to UV
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048041	focal adhesion assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031256	leading edge membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108
PF07679

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt