InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRIK3

Summary

InnateDB Protein

IDBP-96396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK3

Protein Name

glutamate receptor, ionotropic, kainate 3

Synonyms

EAA5; GLR7; GluK3; GLUR7; GluR7a;

Species

Homo sapiens

Ensembl Protein

ENSP00000362183

InnateDB Gene

IDBG-96392 (GRIK3)

Protein Structure

UniProt Annotation

Function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0006810	transport
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0051967	negative regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0032839	dendrite cytoplasm
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043195	terminal bouton
GO:0043204	perikaryon
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt