InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEAF6

Summary

InnateDB Protein

IDBP-96421.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEAF6

Protein Name

MYST/Esa1-associated factor 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362166

InnateDB Gene

IDBG-96417 (MEAF6)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269PubMed:14966270, ECO:0000269PubMed:16387653, ECO:0000269PubMed:18794358}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:18794358}.

Disease Associations

Note=A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1. {ECO:0000269PubMed:22761769}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043968	histone H2A acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0044154	histone H3-K14 acetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0035267	NuA4 histone acetyltransferase complex
GO:0070776	MOZ/MORF histone acetyltransferase complex