Version 5.4
Homo sapiens Protein: DNALI1
Summary
InnateDB Protein IDBP-96440.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNALI1
Protein Name dynein, axonemal, light intermediate chain 1
Synonyms dJ423B22.5; hp28; P28;
Species Homo sapiens
Ensembl Protein ENSP00000296218
InnateDB Gene IDBG-96438 (DNALI1)
Protein Structure
UniProt Annotation
Function May play a dynamic role in flagellar motility.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0045504 dynein heavy chain binding
Biological Process
GO:0006928 cellular component movement
GO:0007338 single fertilization
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005858 axonemal dynein complex
GO:0005930 axoneme
GO:0030175 filopodium
Protein Structure and Domains
PDB ID
InterPro IPR019347 Axonemal dynein light chain
PFAM PF10211
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14645
PhosphoSite PhosphoSite-O14645
TrEMBL
UniProt Splice Variant
Entrez Gene 7802
UniGene Hs.406050
RefSeq NP_003453
HUGO HGNC:14353
OMIM 602135
CCDS CCDS420
HPRD 03681
IMGT
EMBL AF006386 AK290502 AL034379 BC039074 BC046117 BX647913
GenPept AAB69193 AAH39074 AAH46117 BAF83191 CAI20553 CAI46082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca