Version 5.4
Homo sapiens Protein: EPHA10
Summary
InnateDB Protein IDBP-96488.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA10
Protein Name EPH receptor A10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000316395
InnateDB Gene IDBG-96482 (EPHA10)
Protein Structure
UniProt Annotation
Function Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. {ECO:0000269PubMed:15777695}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Mainly expressed in testis. {ECO:0000269PubMed:15777695}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0008150 biological_process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001090 Ephrin receptor ligand binding domain
IPR008979 Galactose-binding domain-like
PFAM PF01404
PRINTS
PIRSF
SMART SM00615
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JZY3
PhosphoSite PhosphoSite-Q5JZY3
TrEMBL
UniProt Splice Variant
Entrez Gene 284656
UniGene Hs.129435
RefSeq NP_775912
HUGO HGNC:19987
OMIM 611123
CCDS CCDS425
HPRD 08163
IMGT
EMBL AC104336 AJ781169 AJ872185 BC067734 BC112933
GenPept AAH67734 AAI12934 CAG77605 CAI43321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca