Version 5.4
Homo sapiens Gene: EPHA10
Summary
InnateDB Gene IDBG-96482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA10
Gene Name EPH receptor A10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183317
Encoded Proteins
IDBP-96486
EPH receptor A10
IDBP-96488
EPH receptor A10
IDBP-380252
EPH receptor A10
IDBP-594807
EPH receptor A10
IDBP-596386
EPH receptor A10
IDBP-593618
EPH receptor A10
IDBP-596175
EPH receptor A10
IDBP-594668
EPH receptor A10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37713880-37765133
Strand Reverse strand
Band p34.3
Transcripts
ENST00000373048 ENSP00000362139
ENST00000319637 ENSP00000316395
ENST00000427468 ENSP00000397746
ENST00000437645 ENSP00000432693
ENST00000444950
ENST00000432874 ENSP00000436425
ENST00000446149
ENST00000453577
ENST00000534097 ENSP00000431389
ENST00000525749 ENSP00000436288
ENST00000540011 ENSP00000441822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008150 biological_process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028876
View Gene Order
ENSBTAG00000020510
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.129435
RefSeq NM_001099439 NM_173641 XM_006710584
HUGO
OMIM
CCDS CCDS41305 CCDS425
HPRD 08163
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca