InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP5B

Summary

InnateDB Protein

IDBP-96526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5B

Protein Name

inositol polyphosphate-5-phosphatase, 75kDa

Synonyms

5PTase;

Species

Homo sapiens

Ensembl Protein

ENSP00000362117

InnateDB Gene

IDBG-96518 (INPP5B)

Protein Structure

UniProt Annotation

Function

Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269PubMed:7721860}.

Subcellular Localization

Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Golgi apparatus.

Disease Associations

Tissue Specificity

Platelets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046856	phosphatidylinositol dephosphorylation
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF03372
PF14529

PRINTS

PIRSF

SMART

SM00324
SM00128

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32019