Version 5.4
Homo sapiens Gene: INPP5B
Summary
InnateDB Gene IDBG-96518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5B
Gene Name inositol polyphosphate-5-phosphatase, 75kDa
Synonyms 5PTase
Species Homo sapiens
Ensembl Gene ENSG00000204084
Encoded Proteins
IDBP-96524
inositol polyphosphate-5-phosphatase, 75kDa
IDBP-96526
inositol polyphosphate-5-phosphatase, 75kDa
IDBP-96528
inositol polyphosphate-5-phosphatase, 75kDa
IDBP-96530
inositol polyphosphate-5-phosphatase, 75kDa
IDBP-96536
inositol polyphosphate-5-phosphatase, 75kDa
IDBP-380372
inositol polyphosphate-5-phosphatase, 75kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37860697-37947057
Strand Reverse strand
Band p34.3
Transcripts
ENST00000373027 ENSP00000362118
ENST00000373026 ENSP00000362117
ENST00000373024 ENSP00000362115
ENST00000373023 ENSP00000362114
ENST00000373021 ENSP00000362112
ENST00000458109 ENSP00000397748
ENST00000487328
ENST00000470364
ENST00000474758
ENST00000467066
ENST00000491406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007283 spermatogenesis
GO:0030317 sperm motility
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0070613 regulation of protein processing
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028894
View Gene Order
ENSBTAG00000024107
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.449942 Hs.606041
RefSeq NM_001297434 NM_005540 XM_005270833 XM_005270835 XM_005270836 XM_006710619 XM_006710620 XM_006710621
HUGO
OMIM
CCDS CCDS41306 CCDS72760
HPRD 00924
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca