InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VNN1

Summary

InnateDB Protein

IDBP-96672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VNN1

Protein Name

vanin 1

Synonyms

HDLCQ8; Tiff66;

Species

Homo sapiens

Ensembl Protein

ENSP00000356905

InnateDB Gene

IDBG-96670 (VNN1)

Protein Structure

UniProt Annotation

Function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269PubMed:10567687, ECO:0000269PubMed:11491533}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. {ECO:0000269PubMed:19322213}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159	pantetheine hydrolase activity
GO:0034235	GPI anchor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006807	nitrogen compound metabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0015939	pantothenate metabolic process
GO:0016337	single organismal cell-cell adhesion
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0045087	innate immune response
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway