InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PABPC4

Summary

InnateDB Protein

IDBP-96719.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PABPC4

Protein Name

poly(A) binding protein, cytoplasmic 4 (inducible form)

Synonyms

APP-1; APP1; iPABP; PABP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000361947

InnateDB Gene

IDBG-96711 (PABPC4)

Protein Structure

UniProt Annotation

Function

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396	RNA processing
GO:0006401	RNA catabolic process
GO:0006412	translation
GO:0007596	blood coagulation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003954 RNA recognition motif domain, eukaryote
IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

PFAM

PF00076
PF00658

PRINTS

PIRSF

SMART

SM00360
SM00517
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13310