InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NT5C1A

Summary

InnateDB Protein

IDBP-96742.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NT5C1A

Protein Name

5'-nucleotidase, cytosolic IA

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000235628

InnateDB Gene

IDBG-96740 (NT5C1A)

Protein Structure

UniProt Annotation

Function

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia. {ECO:0000269PubMed:11133996}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas. {ECO:0000269PubMed:11133996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0008253	5'-nucleotidase activity

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0009116	nucleoside metabolic process
GO:0009117	nucleotide metabolic process
GO:0009128	purine nucleoside monophosphate catabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046085	adenosine metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process