InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIE

Summary

InnateDB Protein

IDBP-96754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIE

Protein Name

peptidylprolyl isomerase E (cyclophilin E)

Synonyms

CYP-33; CYP33;

Species

Homo sapiens

Ensembl Protein

ENSP00000312769

InnateDB Gene

IDBG-96746 (PPIE)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016018	cyclosporin A binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0000413	protein peptidyl-prolyl isomerization
GO:0006355	regulation of transcription, DNA-templated
GO:0006457	protein folding
GO:0045070	positive regulation of viral genome replication

Cellular Component

GO:0005634	nucleus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR016304 Cyclophilin-type peptidyl-prolyl cis-trans isomerase E
IPR029000 Cyclophilin-like domain

PFAM

PF00076
PF00160

PRINTS

PR00153

PIRSF

PIRSF001475

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References