InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OXCT2

Summary

InnateDB Protein

IDBP-96772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXCT2

Protein Name

3-oxoacid CoA transferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361914

InnateDB Gene

IDBG-96770 (OXCT2)

Protein Structure

UniProt Annotation

Function

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11756565}.

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:11756565}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008260	3-oxoacid CoA-transferase activity
GO:0008410	CoA-transferase activity

Biological Process

GO:0008152	metabolic process
GO:0046952	ketone body catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0031514	motile cilium

Protein Structure and Domains

PDB ID

InterPro

IPR004165 Coenzyme A transferase family I
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR014388 3-oxoacid CoA-transferase

PFAM

PF01144

PRINTS

PIRSF

PIRSF000858

SMART

SM00882

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt