InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP7

Summary

InnateDB Protein

IDBP-96926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP7

Protein Name

microtubule-associated protein 7

Synonyms

E-MAP-115; EMAP115;

Species

Homo sapiens

Ensembl Protein

ENSP00000346581

InnateDB Gene

IDBG-96924 (MAP7)

Protein Structure

UniProt Annotation

Function

Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269PubMed:11719555, ECO:0000269PubMed:8408219, ECO:0000269PubMed:9989799}.

Subcellular Localization

Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.

Disease Associations

Tissue Specificity

Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. {ECO:0000269PubMed:8408219, ECO:0000269PubMed:9989799}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006970	response to osmotic stress
GO:0007163	establishment or maintenance of cell polarity
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0015630	microtubule cytoskeleton
GO:0016323	basolateral plasma membrane
GO:0048471	perinuclear region of cytoplasm