InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTPS1

Summary

InnateDB Protein

IDBP-97082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS1

Protein Name

CTP synthase

Synonyms

CTPS; IMD24;

Species

Homo sapiens

Ensembl Protein

ENSP00000361699

InnateDB Gene

IDBG-97078 (CTPS1)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. {ECO:0000269PubMed:16179339}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0042493	response to drug
GO:0044210	'de novo' CTP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004468 CTP synthase
IPR011697 Peptidase C26
IPR017456 CTP synthase, N-terminal
IPR017926 Glutamine amidotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029062 Class I glutamine amidotransferase-like

PFAM

PF07722
PF06418
PF00117

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17812

PhosphoSite