InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDN2

Summary

InnateDB Protein

IDBP-97146.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDN2

Protein Name

endothelin 2

Synonyms

ET-2; ET2; PPET2;

Species

Homo sapiens

Ensembl Protein

ENSP00000361668

InnateDB Gene

IDBG-97144 (EDN2)

Protein Structure

UniProt Annotation

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in lung, but not in placental stem villi vessels or cultured placental villi smooth muscle cells. {ECO:0000269PubMed:9284755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001659	temperature homeostasis
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003058	hormonal regulation of the force of heart contraction
GO:0003099	positive regulation of the force of heart contraction by chemical signal
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007166	cell surface receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014824	artery smooth muscle contraction
GO:0014826	vein smooth muscle contraction
GO:0019221	cytokine-mediated signaling pathway
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0030593	neutrophil chemotaxis
GO:0042116	macrophage activation
GO:0042310	vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0048016	inositol phosphate-mediated signaling
GO:0048246	macrophage chemotaxis
GO:0048286	lung alveolus development
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009	energy homeostasis