InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUCA2B

Summary

InnateDB Protein

IDBP-97169.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCA2B

Protein Name

guanylate cyclase activator 2B (uroguanylin)

Synonyms

GCAP-II; UGN;

Species

Homo sapiens

Ensembl Protein

ENSP00000361662

InnateDB Gene

IDBG-97167 (GUCA2B)

Protein Structure

UniProt Annotation

Function

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Stomach and intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008048	calcium sensitive guanylate cyclase activator activity
GO:0030250	guanylate cyclase activator activity

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007588	excretion
GO:0007589	body fluid secretion
GO:0030802	regulation of cyclic nucleotide biosynthetic process
GO:0031284	positive regulation of guanylate cyclase activity
GO:0045776	negative regulation of blood pressure